Maiante, A.A., Teixeira Neto, F.J., Beier, S.L., Corrente, J.E. and Pedroso, C.E.B.P. (2009). Comparison of cardio-dash; Respiratory effects of methadone and morphine in conscious dogs. Journal of veterinary pharmacology and therapeutics. 32 (4) : 317-328. Physicians who prescribe methadone in Alberta continue to apply for OAT admission by the College of Physicians and Surgeons of Alberta (CPSA) and must reapply every three years. Current exceptions are still active, but they must be extended after they expire. If pharmacists receive a methadone prescription from an Alberta physician, they must send all confirmation requests to CPSA at 780-423-4764 or 1-800-561-3899 or e-mail firstname.lastname@example.org. In this study, the concomitant administration of acepromazine (0.05 mg/kg) with methadone resulted in severe sedation in most dogs. The increase in the dose of methadone (0.25, 0.50 and 0.75 mg/kg) prolonged the dose-dependent calming effect, but had no effect on the rate of sedation. It is important to modify the cardiopulmonary variables measured after the administration of medications in these healthy dogs were well tolerated and not clinically relevant.
Acepromazine is the most commonly used drug in dogs. Previous reports have shown that intravenous (IV) or IM administration of acepromazine (0.05 to 0.1 mg/kg) in dogs resulted in mild to moderate sedation (Monteiro et al. 2008). Gomes et al. 2011). Consistent with these results, the administration of acepromazine alone at 0.05 mg/kg in this study resulted, in most cases, in mild to moderate sedation. As of May 2018, Health Canada will no longer require a methadone prescription to obtain a federal exemption under Section 56 of the Controlled Drugs and Substances Act, and this oversight is now the responsibility of the various provincial supervisory authorities. Any licensed pharmacist can deliver methadone and buprenorphine naloxone. No exemptions or authorizations are required.
Nurses (NPs) are not required to apply to CARNA for permission to prescribe methadone. On the contrary, they must complete the training and training of orders according to the scope of their prescription and must provide proof of them only upon REQUEST from CARNA. All drugs were administered intramuscularly (IM) and were mixed in the AM0.25, AM0.50 and AM0.75 groups with acepromazine and methadone in a single syringe before administration. The main side effects of methadone combined with acepromazine were a decrease in blood pressure, a slight decrease in respiratory acid and a decrease in rectal temperature. These effects were well tolerated and resolved without treatment.